Exploring local delivery of oral biologics
Plantibodies is developing oral delivery approaches designed to protect biologics during gastrointestinal transit and release them in the colon. Understanding how a therapeutic protein may move through the colonic environment is an important part of evaluating its potential for local action.
This interactive simulator provides an exploratory framework for examining the influence of selected formulation and biological parameters on modeled protein distribution. Users can explore the effects of protein size, target location, tissue compartments, cell-penetrating peptides and permeation enhancers.
The model represents a one-dimensional transport calculation across the colon, displayed using a schematic three-dimensional visualization. Its parameters are currently hypothetical and have not been calibrated to clinical or formulation-specific data. The results are intended for research and discussion; they should not be interpreted as predictions of human exposure, efficacy, safety or dosing.